parathyroid hormone (1-34) (human) Search Results


teriparatide human parathyroid hormone 1 34  (Tocris)
90
Tocris teriparatide human parathyroid hormone 1 34
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Teriparatide Human Parathyroid Hormone 1 34, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parathyroid+hormone+(1-34)+(human)/Parathyroid+hormone+(1-34)+(human)/pmc11205257-414-55-63
Average 90 stars, based on 1 article reviews
teriparatide human parathyroid hormone 1 34 - by Bioz Stars, 2026-09
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teriparatide  (MedChemExpress)
94
MedChemExpress teriparatide
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Teriparatide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parathyroid+hormone+(1-34)+(human)/Teriparatide/pmc12178744-71-0-1
Average 94 stars, based on 1 article reviews
teriparatide - by Bioz Stars, 2026-09
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human parathyroid hormone  (R&D Systems)
93
R&D Systems human parathyroid hormone
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Human Parathyroid Hormone, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parathyroid+hormone+(1-34)+(human)/Parathyroid+hormone+(1-34)+(human)/pmc05508733-749-15-20
Average 93 stars, based on 1 article reviews
human parathyroid hormone - by Bioz Stars, 2026-09
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human parathyroid hormone  (Thermo Fisher)
94
Thermo Fisher human parathyroid hormone
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Human Parathyroid Hormone, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parathyroid+hormone+(1-34)+(human)/PARATHYROID+HORMONE+1+34+HUMAN/10__1074_slash_jbc__m510146200-52-9-15
Average 94 stars, based on 1 article reviews
human parathyroid hormone - by Bioz Stars, 2026-09
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teriparatide 1–34 fragment of recombinant human parathyroid hormone  (Lilly Deutschland GmbH)
90
Lilly Deutschland GmbH teriparatide 1–34 fragment of recombinant human parathyroid hormone
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Teriparatide 1–34 Fragment Of Recombinant Human Parathyroid Hormone, supplied by Lilly Deutschland GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parathyroid+hormone+(1-34)+(human)/teriparatide+1+34+fragment+of+recombinant+human+parathyroid+hormone/pmc06331490-66-13-23
Average 90 stars, based on 1 article reviews
teriparatide 1–34 fragment of recombinant human parathyroid hormone - by Bioz Stars, 2026-09
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recombinant human parathyroid hormone related protein (pthrp 1-34)  (FUJIFILM)
90
FUJIFILM recombinant human parathyroid hormone related protein (pthrp 1-34)
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Recombinant Human Parathyroid Hormone Related Protein (Pthrp 1 34), supplied by FUJIFILM, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parathyroid+hormone+(1-34)+(human)/recombinant+human+parathyroid+hormone+related+protein++pthrp+1+34+/pm35237179-50-0-11
Average 90 stars, based on 1 article reviews
recombinant human parathyroid hormone related protein (pthrp 1-34) - by Bioz Stars, 2026-09
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human parathyroid hormone (hpth, 1-34 or 1-84)  (Ayerst Laboratories)
90
Ayerst Laboratories human parathyroid hormone (hpth, 1-34 or 1-84)
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Human Parathyroid Hormone (Hpth, 1 34 Or 1 84), supplied by Ayerst Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parathyroid+hormone+(1-34)+(human)/human+parathyroid+hormone++hpth++1+34+or+1+84+/10__1111_slash_jbmr__1999__14__s1__1-27497-15-5
Average 90 stars, based on 1 article reviews
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recombinant human parathyroid hormone (1–34) n-terminally monopegylated hpth(1–34)  (ScinoPharm limited)
90
ScinoPharm limited recombinant human parathyroid hormone (1–34) n-terminally monopegylated hpth(1–34)
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Recombinant Human Parathyroid Hormone (1–34) N Terminally Monopegylated Hpth(1–34), supplied by ScinoPharm limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parathyroid+hormone+(1-34)+(human)/recombinant+human+parathyroid+hormone++1+34++n+terminally+monopegylated+hpth+1+34+/pm25168862-29-17-71
Average 90 stars, based on 1 article reviews
recombinant human parathyroid hormone (1–34) n-terminally monopegylated hpth(1–34) - by Bioz Stars, 2026-09
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recombinant human parathyroid hormone pth 1-34  (Current Science Inc)
90
Current Science Inc recombinant human parathyroid hormone pth 1-34
(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
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(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
Recombinant Human Parathyroid Hormone (1– 34), supplied by Current Science Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
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(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), <t>teriparatide</t> (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.
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(A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), teriparatide (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.

Journal: Science (New York, N.Y.)

Article Title: A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors

doi: 10.1126/science.abq8173

Figure Lengend Snippet: (A) Primary cultured rat cortical neurons expressing SST1.0 (A1) or CRF1.0 (A2), showing sensor expression (left), pseudocolor responses (middle), and cell membrane localization (right). Scale bars, 100 μm (left) and 20 μm (right). (B) Example fluorescence traces (left) and summary data (right) of neurons expressing SST1.0 (B1) or CRF1.0 (B2); where indicated, peptides and antagonists were applied (n = 66 to 115 ROIs from three or four coverslips). (C) Normalized dose-response curves of neurons expressing SST1.0 (C1) or CRF1.0 (C2) in response to the indicated ligands; n = 3 cultures each with 20 to 40 ROIs. (D) Summary of the fluorescence change measured in neurons expressing SST1.0 (D1) or CRF1.0 (D2) in response to a 2-hour continuous application of 1 μM SST-14 or 300 nM CRF, respectively; n = 4 cultures each with 20 to 40 ROIs. (E) Summary of normalized ΔF/F0 in HEK293T cells expressing SST1.0 (left) or CRF1.0 (right) in response to the indicated compounds applied: SST-14, CRF, UCN2, UCN3, CCK-8s, NPY, NTS, VIP, pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotropic hormone (ACTH), β-melanocyte-stimulating hormone (β-MSH), γ-MSH, growth hormone-releasing hormone (GHRH), oxytocin (OT), vasopressin (AVP), vosotocin, isotocin, glucagon, glucagon-like peptide (GLP-1), DAMGO, dynorphin A (DynA), enkephalin (Enk), goserelin, ghrelin, galanin, orexin A (OX-A), SP, neurokinin B (NKB), and bombesin (BB) were applied at 1 μM, while Glu, GABA, DA, norepinephrine (NE), serotonin (5-HT), histamine (HA), ATP, ADP, adenosine (Ado), teriparatide (TPTD), and taltirelin were applied at 10 μM (n = 4 wells containing 100 to 300 cells per well). (F and G) G protein and β-arrestin coupling were measured using the split-luciferase complementation assay (F1), a cyclic adenosine monophosphate (cAMP) reporter (F2), and the Tango assay (G1 and G2) in cells expressing either the wild-type peptide receptor (red), sensor (green), or no receptor (Ctrl; gray) in the presence of the indicated concentrations of the ligand; n = 3 wells each. AU, arbitrary units. (H) RNA-seq analysis shows that GRAB peptide sensors did not alter the cellular transcriptome. Comparisons of transcriptomes between cortex tissue expressing SST1.0 or EGFP-CAAX (H1) and between CRF1.0 or EGFP-CAAX (H2). Pearson's correlation coefficient analysis was used to evaluate the differential RNA expression.

Article Snippet: Where indicated, the following compounds were applied to the cells in Tyrode’s solution by bath application or a custom-made perfusion system: SST-28 (Anaspec), SST-14 (Anaspec), CCK-8s (Abcam), CCK-4 (Abcam), CRF (Anaspec), UCNI (MedChemExpress), UCNII (MedChemExpress), UCNIII (Abcam), NTS (Anaspec), NPY (Abcam), VIP (Anaspec), PACAP(1–38) (MedChemExpress), PACAP(1–27) (MedChemExpress), Orexin-B (GL Biochem), Substance P (Tocris), Ghrelin (Tocris), teriparatide [human parathyroid hormone-(1–34)] (MedChemExpress), Glu (Sigma-Aldrich), GABA (Tocris), DA (Sigma-Aldrich), NE (Tocris), 5-HT (Tocris), HA (Tocris), ATP (Tocris), ADP (MedChemExpress), Ado (Tocris), ACTH (MedChemExpress), β-MSH (MedChemExpress), γ-MSH (MedChemExpress), GHRH (Anaspec), OT (Anaspec), AVP (Tocris), vasotocin (MedChem-Express), isotocin (KS-V peptide), glucagon (GLPBIO), GLP-1 (MedChemExpress), DAMGO (Tocris), dynorphin A (Tocris), [Leu5]-enkephalin (MedChemExpress), goserelin (MedChemExpress), galanin (Tocris), orexin-A (Tocris), NKB (Tocris), bombesin (MedChemExpress), taltirelin (MedChemExpress), BIM23056 (Abcam), YM 022 (Tocris), NBI 27914 (Santa Cruz), antalarmin (Cayman), α-helical CRF (Tocris), SR142948 (Tocris), BIBO 3304 (Tocris), and PACAP(6–38) (Tocris).

Techniques: Cell Culture, Expressing, Membrane, Fluorescence, Luciferase, RNA Sequencing, RNA Expression